LAB DAY Host
Susan A. Slaugenhaupt, PhD
Elizabeth G. Riley and Daniel E. Smith, Jr. MGH Research Scholar 2013-2018
Scientific Director, Mass General Research Institute
Dr. Slaugenhaupt is the scientific director of the Mass General Research Institute, a professor in the Department of Neurology at Mass General and Harvard Medical School and an investigator in the Center for Genomic Medicine at Mass General. She is a member of the Research Institute Steering Committee and an ex- officio member of the Research Institute Advisory Council.
Dr. Slaugenhaupt and her Research Institute team promote science at Mass General by increasing interactions with industry and fundraising for Research Institute initiatives, including partnering with individual philanthropists, their families and foundations and promoting Mass General research to the community through events and social media.
Her own research focuses on understanding the genetic basis of human disease and translating discoveries into therapies and improved clinical care for patients. Dr. Slaugenhaupt is investigating two neurological disorders, familial dysautonomia (FD) and mucolipidosis type IV (MLIV) and the common cardiac disorder mitral valve prolapse (MVP). The discoveries in Dr. Slaugenhaupt’s laboratory have led to the successful implementation of population screening for FD and MLIV. Her team’s more recent discovery of a drug that modifies mRNA splicing has led to a clinical trial of the first therapeutic for FD that directly targets the molecular defect. Dr. Slaugenhaupt’s team has also successfully developed a potential treatment for a genetic disease that directly targets the mRNA splicing mechanism.
In 2013, Dr. Slaugenhaupt was named the Elizabeth G. Riley and Daniel E. Smith, Jr. MGH Research Scholar 2013-2018. In 2016, she was honored with a prestigious Javits Neuroscience Investigator Award by the National Institute for Neurological Disorders and Stroke (NINDS) at NIH, and she was named one of the 2016 Top Ten Women to Watch in Science and Technology by the Boston Business Journal. In 2020, Dr. Slaugenhaupt was appointed inaugural incumbent of the Elizabeth G. Riley and Daniel E. Smith, Jr. Endowed MGH Research Institute Chair.
Lab Tour Hosts
Matthew Rosen, PhD
Kiyomi and Ed Baird MGH Research Scholar 2022-2027
Associate Investigator, Martinos Center for Biomedical Imaging
Dr. Matt Rosen is a physicist, tool-builder and inventor whose research bridges the spectrum from fundamental physics to transformative clinical solutions in the field of magnetic resonance imaging (MRI).
Dr. Rosen has built a career around identifying big-picture needs and responding with creative solutions that span academic disciplines and push the boundaries of innovation. Since establishing his laboratory at MGH’s Martinos Center in 2009, he has led a program to develop tools and techniques for low-cost, low-magnetic-field implementations of MRI focused on brain imaging. This work includes the development and construction of a laboratory MRI scanner operating at ultra-low magnetic field which was the proof of principle for a new generation of medical imaging capabilities that are profoundly affecting clinical care today.
In 2014, his academic work in this space led him to the founding of a company that has realized the first portable MRI brain scanner for human clinical diagnosis. The award-winning, FDA-approved low-field Hyperfine MRI scanner can be easily moved to and operated in any location in a hospital or beyond. MGH has some of the first Hyperfine MRI scanners and many hospitals around the world are now acquiring these transformative devices, including remote and resource-limited countries like Uganda and Malawi.
In 2021, he was elected a Fellow of the American Physical Society for his work in “medical imaging through the development and commercialization of low-field human MRI scanners, for the development of automated transform by manifold approximation (AUTOMAP), a general AI-based image reconstruction framework, and for unique spin hyperpolarization techniques.”
Dr. Rosen is an inventor on more than 19 issued patents, several of which have been licensed to industry. He has co-founded five companies and has served on the scientific advisory boards of nine companies since 2014. He is the Kiyomi and Ed Baird MGH Research Scholar 2022-2027, the Director of the Low Field MRI and Hyperpolarized Media Lab, and the Co-Director of the Center for Machine Learning at the MGH/Martinos Center. He is an Associate Professor of Radiology at Harvard Medical School.
Shannon Stott, PhD
d’Arbeloff MGH Research Scholar 2022-2027
Assistant Investigator, Mass General Cancer Center
Shannon Stott, PhD, is a mechanical engineer that works at the interface of technology and medicine. She is the first engineer to be a faculty member at the Mass General Cancer Center and holds appointments at the Center for Engineering in Medicine and Surgery and the Department of Medicine at Harvard Medical School.
Dr. Stott’s research focuses on “liquid biopsy” approaches, or simply, testing biofluids like blood and saliva for important biomarkers. She uses her expertise in microfluidics, optics and biopreservation to develop new tools for clinical medicine. She invented the herringbone circulating tumor cell chip (HBCTC-Chip), a device that can successfully capture extremely rare cancer cells circulating in the bloodstream of cancer patients. Manipulating blood flow for the isolation and separation of biological components has been a hallmark of her work. Recent efforts include using microfluidics to separate extracellular vesicles and nucleic acids from patient samples.
The primary goal of the Stott Laboratory is to use these technologies and techniques to improve patient lives through early diagnosis and a greater understanding of how cancer spreads and kills. Dr. Stott has a particular interest in brain tumors and the potential impact of a blood biopsy for adult and pediatric patients. Dr. Stott has twelve patents issued or pending, and her research has been highlighted in Nature, Science, CNN, and MIT Technology Review.
Prior to being named the d’Arbeloff MGH Research Scholar 2022-2027, Dr. Stott had been awarded the American Cancer Society’s Women Leading the Way to Wellness Award, the 2021 MGH Research Institute Excellence in Mentoring Award and was a National Academies Frontiers of Science Scholar.
Lunch and Learn Presenter
Travis Baggett, MD, MPH
MGH Research Scholar 2021-2026
Physician-Investigator, Division of General Internal Medicine, MGH
Travis P. Baggett, MD, MPH is a physician-investigator in the MGH Division of General Internal Medicine, an Associate Professor of Medicine at Harvard Medical School, and the Director of Research at Boston Health Care for the Homeless Program, where he also practices primary care.
Dr. Baggett’s research focuses on the health of the approximately 580,000 people who are homeless in the U.S. at any given time. Working in close partnership with Boston Health Care for the Homeless Program, he has conducted numerous innovative studies describing the burden, consequences, and management of conditions seen commonly in homeless health care settings. He is the principal investigator of two large intervention trials for homeless individuals: one examining financial incentives for smoking cessation and one examining patient navigation to promote lung cancer screening. In parallel, his epidemiologic studies have highlighted the impact of the opioid epidemic among people experiencing homelessness, who die of drug overdose at rates 16-30 times higher than non-homeless individuals.
Prior to being named an MGH Research Scholar 2021-2026, Dr. Baggett was an inaugural member of the Department of Medicine’s Transformative Scholars Program and the recipient of the 2019 Stephen M. Krane, MD, Lectureship Award.
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